Design, Synthesis, Characterization and Anticancer Properties of Novel 2-Chloro-N-(Aryl Substituted) Acetamide Derivatives of 5-[2-(4- Methoxyphenyl) Pyridin-3-yl]-1, 3, 4-Oxadiazole-2-Thiol

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dc.contributor.authorAdimule, Vinayak
dc.contributor.authorMedapa, Sudha
dc.contributor.authorKumar, S lalita
dc.contributor.authorRao, Prakash Kumar
dc.date.accessioned2017-06-12T05:30:25Z
dc.date.available2017-06-12T05:30:25Z
dc.date.copyright2014en_US
dc.description.abstractIn this linear synthesis, novel different 2-chloro N-aryl substitutedacetamide derivatives of 5-[2-(4-methoxyphenyl) pyridin-3-yl]-1, 3, 4-oxadiazole-2-thiol have been synthesized and screened for their cytotoxicity on PANC-1, HepG2 and MCF7 cell lines and obtained the IC50 and CC50 values.All the synthesized compounds were characterized by LCMS, IR, 1H and 13C (proton and Carbon 13) spectroscopies and elemental analysis. These compounds were evaluated for invitro anticancer activity on three different human leukemic cell lines, namely PANC-1,HepG2 and MCF7.In total five compounds were synthesized and studied for their MTT assay. Among five synthesized novel compounds, the compound N- [5-(4-Methoxy-phenyl)-pyridin-2-yl]-2-{5-[2-(4-methoxy-phenyl)-pyridin-3- yl][1,3,4]oxadiazol-2-ylsulfanyl}-acetamide6e is highly cytotoxic on PANC-1 and HepG2 cell lines having IC50 of 4.6μM and 2.2μM respectively whereas the compound 6c is moderately cytotoxic on MCF7 having IC50 15.5μM respectively. Rest all the compounds showed less cytotoxicity on all the three cell lines as compared with the standard 5-FU.en_US
dc.description.searchVisibilitytrueen_US
dc.description.urihttp://www.ijddr.in/drug-development/design-synthesis-characterization-and-anticancer-properties-of-novel2chloronaryl-substituted-acetamide-derivatives-of-524methoxyphenyl-pyridin3yl1-3-4oxadiazole2thiol.pdfen_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.issn0975-9344 |en_US
dc.identifier.urihttp://www.ijddr.in/drug-development/design-synthesis-characterization-and-anticancer-properties-of-novel2chloronaryl-substituted-acetamide-derivatives-of-524methoxyphenyl-pyridin3yl1-3-4oxadiazole2thiol.pdfen_US
dc.identifier.urihttp://www.ignou.ndl.iitkgp.ac.in:8080/xmlui/handle/123456789/22
dc.language.isoengen_US
dc.publisherInsight Medical Publishingen_US
dc.publisher.date2014-12
dc.publisher.placeDelaware, USAen_US
dc.relation.requiresPDF viewer Pluginen_US
dc.rights.accessRightsndlen_US
dc.sourceIGNOUen_US
dc.source.urihttp://www.ignou.ac.in/en_US
dc.subjectHepG2, 1, 3, 4-Oxadiazoles, Chloroacetyl chloride, acetamide, MTT assayen_US
dc.subject.ddc540en_US
dc.subject.otherchemistryen_US
dc.titleDesign, Synthesis, Characterization and Anticancer Properties of Novel 2-Chloro-N-(Aryl Substituted) Acetamide Derivatives of 5-[2-(4- Methoxyphenyl) Pyridin-3-yl]-1, 3, 4-Oxadiazole-2-Thiolen_US
dc.typetexten_US
lrmi.educationalAlignment.difficultyLevelmediumen_US
lrmi.educationalAlignment.educationalFrameworkUniversity Grants Commission (UGC)en_US
lrmi.educationalAlignment.educationalLevelug_pgen_US
lrmi.educationalAlignment.pedagogicObjectiveFor Academic and research useen_US
lrmi.educationalRoleteacheren_US
lrmi.educationalUseresearchen_US
lrmi.interactivityTypemixeden_US
lrmi.learningResourceTypearticleen_US
lrmi.typicalAgeRange22+en_US
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